Interviewee: Herbert Boyer.
Herb Boyer talks about Stanley Cohen's and his interest in plasmids as vectors for DNA.
(DNAi Location: Manipulation > Revolution > Players > Herbert Boyer and Stanley Cohen > Interest in plasmids)
We both had an interest in plasmids, these are small mini-chromosomes, usually non-essential for bacterial existence. But they had a strong medical importance because these plasmids carried genes that gave bacteria resistance to antibiotics, so they have a big medical importance, and Stanley had an interest in them. Also because they were small pieces of DNA they could be isolated and some of their properties could be manipulated and you could do experiments with them.
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Stanley Cohen and Herbert Boyer inserted the recombinant DNA molecule they created into E. coli bacteria by means of a plasmid, thereby inducing the uptake and expression of a foreign DNA sequence known as "transformation."
Herbert Boyer: Former varsity lineman turned biotech bigwig. Expert at cutting DNA before most people knew it could be done.
Stanley Cohen: A born tinkerer; figured out the trick of using loops of DNA called plasmids to transform bacterial DNA
Image of Herbert Boyer. From lineman on the varsity football team to co-founder of the first biotech company, Boyer has never lacked imagination, drive, or vision. His and Stanley Cohen's recombinant DNA work paved the way for the biotech revolution.