Making GeneChips™ at Affymetrix

Affymetrix, the makers of GeneChip arrays. GeneChips help scientists identify genetic variations associated with diseases such as cancer. This information can be used to develop better methods for diagnosis and treatment. What you see here is the GeneChip production facility. GeneChips consist of hundreds of thousands of different DNA probes printed on quartz wafers. To assemble these probes on wafers, technicians alternate between a special printing process called photolithography and DNA synthesis. Here, photolithography is done on the left, and DNA synthesis is done on the right.

Genechip image 1

Welcome to Affymetrix, the makers of GeneChip arrays! GeneChips help scientists identify genetic variations associated with diseases such as cancer. This information can be used to develop better methods for diagnosis and treatment. What you see here is the GeneChip production facility. GeneChips consist of hundreds of thousands of different DNA probes printed on quartz wafers. To assemble these probes on wafers, technicians alternate between a special printing process called photolithography and DNA synthesis. Here, photolithography is done on the left, and DNA synthesis is done on the right.

quartz wafers,dna probes,dna synthesis,genetic variations,photolithography,printing process,arrays,hundreds of thousands,diagnosis,diseases,scientists,cancer

  • ID: 15661
  • Source: DNALC.DNAi

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15662. Making GeneChips™ at Affymetrix

Here you can see a technician shuttling a quartz wafer (containing 50-400 GeneChips™) between alternating photolithography and DNA synthesis steps.

  • ID: 15662
  • Source: DNAi

15666. Making GeneChips® at Affymetrix

The quartz wafer is in the holding position on the DNA synthesizer. The wafer is moved to a vertical reaction vessel for the process of DNA chain elongation.

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  • Source: DNALC.DNAi

15665. Making GeneChips™ at Affymetrix

A technician loads a quartz wafer into the DNA synthesizer, where nucleotides will be added to selected sequences to build probes.

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16736. Animation 36: Different genes are active in different kinds of cells.

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