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ID 15880

Models of DNA replication

Description:
Three different models of DNA replication were proposed. Matt Meselson and Frank Stahl's experiment supported only one of the models.
Keywords:
replication models,dna replication,meselson,models of dna,stahl
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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15879. Semi-conservative replication
Matt Meselson and Frank Stahl's
15331. Proposed models of DNA replication, Matthew Meselson
Matt Meselson talks about the different models that were considered before their experiment.
16461. Video 20: Matthew Meselson, clip 2
The three models of DNA replication - semi-conservative, conservative, and dispersive - and whether bias played a role in designing/interpreting the experiment.
16469. Problem 20: A half DNA ladder is a template for copying the whole.
Explore other theories on DNA replication.
16466. Biography 20: Matthew Stanley Meselson (1930- )
Matthew Meselson and Franklin Stahl invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
15332. Use of isotopes to determine correct DNA replication model, Matthew Meselson
Matt Meselson describes the experiment he did with Frank Stahl to prove that DNA is replicated semi-conservatively.
15461. The double helix and the Nobel Prize, James Watson
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16467. Biography 20: Franklin William Stahl (1929-)
Franklin Stahl and Matthew Meselson invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
16443. Animation 20: A half DNA ladder is a template for copying the whole
Matthew Meselson and Franklin Stahl show how new DNA is made by copying the old.
15329. How the second paper (on the replication of DNA) was written, Matthew Meselson
Matt Meselson talks about how he and Frank were "encouraged" by Max Delbruck to write up the results of their experiment on semi-conservative DNA replication.
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