Website Search
ID 15529

Radiation can cause DNA mutations, 3D animation with narration

Description:
Mutations are the grist of evolution, and have accumulated in our DNA over time. When populations separate, each group accumulates their own unique set of DNA mutations. Because mutations in a particular sequence of DNA occur at a constant rate, the number of accumulated mutations in that sequence is proportional to the length of time that two groups have been separated. This concept is often known as the "molecular clock." (DNAi Location: Application > Human Origins > Gene geneaolgoy > A molecular clock > DNA mutation)
Transcript:
DNA is under constant attack from reactive chemicals and natural background radiation. Free radicals are the byproducts of normal metabolism in human cells. Seen here as bright particles, they sometimes react with DNA and cause chemical changes. Radiation can also affect DNA. For example, ultraviolet light from the sun can cause harmful chemical changes in the DNA of skin. These changes can lead to kinks in the DNA that prevent genes from being correctly read, or deletions that alter the type of protein produced. Thanks to constant biochemical repair work, most mutations are corrected before that have any effect. But in rare cases mutations can accumulate, and this can give rise to diseases such as cancer.
Keywords:
natural background radiation,harmful chemical changes,dna mutations,cause chemical changes,dna mutation,molecular clock,reactive chemicals,human origins,free radicals,human cells,constant rate,byproducts,grist,rare cases,ultraviolet light,narration,deletions,length of time,metabolism,genes
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

15980. Accumulating mutations
Mutations are the grist of evolution, and have accumulated in our DNA over time. When populations separate, each group accumulates their own unique set of DNA mutations.
16587. Concept 27: Mutations are changes in genetic information.
Some mutations are starting points for evolution, others are responsible for disease.
15178. Mitochondrial DNA and the molecular clock, Douglas Wallace
Geneticist Douglas Wallace explains a method of mapping a population's history using the mutations accumulated by its members.
991. Causes, Mold: Aflatoxin, Kensler
Professor Kensler explains that Aflatoxin is a lipid soluble molecule that is rapidly absorbed and it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical.
988. Causes, mold
Aflatoxin, a byproduct of molds, is a potent cancer-causing agent. Long-term exposure to aflatoxin has been linked to increased incidence of liver cancer.
982. Causes, Diet: Cause
Meat cooked at high temperatures can produce chemicals that are damaging to cells and DNA.
989. Causes, Mold: Aflatoxin
In this section learn how Aflatoxin a contaminating byproduct of mold caused liver cancer in animals and solicited strict guidelines to regulate the levels of Aflatoxin in the U.S. food supply today.
15168. Accumulating DNA mutations through time, Mark Stoneking
Geneticist Mark Stoneking talks about the difficulties of measuring time by mutations.
15152. Isolating ancient DNA, Svante Paabo
Evolutionary geneticist Svante Paabo speaks about the limitations of working with DNA from fossils.
829. A Gene for Pain
Different mutations in a single gene, SCN9A, demonstrate how much about pain remains mysterious.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving